Major Death Coming In 'Doctor Who'? Official magazine claims that one of the core-four could depart the series in the opening episode
(click to enlarge)Amy has been such a huge part of the marketing for the last year that I can't believe they'd kill her off.
While Rory isn't quite so prominent, I just think that after killing him 2 or 3 times last year that it would be an anticlimax for it to be him.
We've already seen River Song's death in "The Library".
But Moffatt has said that River Song's story will be wrapped up this year.
This will be I think her first meeting with the Doctor, and his last.
So I think it will be her, with some trademark Moffatt timey-wimey.
Or it could be a clone/duplicate of any of the four.
Anyway, I hate spoilers. So I won't be trying to find out.